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MKI-2

MASTL Inhibitor

MKI-2 is a selective MASTL inhibitor with an IC50 of 37.44 nM, effectively targeting the MASTL-PP2A signaling axis. This compound promotes mitotic catastrophe in breast cancer cells by reducing phospho-ENSA and total phospho-c-Myc levels, leading to decreased cell proliferation and migration, as well as increased DNA damage. Additionally, MKI-2 has been shown to inhibit germinal vesicle breakdown in mouse oocytes, making it a valuable tool for cancer research, particularly in the context of breast cancer.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	438204-56-9
Applications	MASTL Inhibitor
Formula	C₂₂H₁₉N₇
Molecular Weight	381.43
SMILES	N#CCC1=CC=C(NC2=NC(NC3=NNC(C4CC4)=C3)=C5C=CC=CC5=N2)C=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.