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ML-93

SAE Inhibitor

ML-93 is an orally active inhibitor of SUMO-conjugating enzyme (SAE) with an IC50 value of 0.4 μM. It effectively disrupts the SUMOylation pathway in HCT116 colorectal carcinoma cells, leading to significant antitumor activity in xenograft models. ML-93 serves as a valuable tool for investigating the role of SUMOylation in colorectal cancer and for exploring potential therapeutic interventions.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1858275-91-8
Applications	SAE Inhibitor
Formula	C₂₅H₂₇ClN₄O₆S₂
Molecular Weight	579.09
SMILES	CC1=C(C=C(S1)C(C2=CN=CN=C2N[C@@H]3C[C@@H]([C@H](C3)O)COS(N)(=O)=O)=O)[C@H]4C5=CC(Cl)=CC=C5CCO4

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.