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ML121

VIM-2 Inhibitor

ML121 is a potent and selective inhibitor of VIM-2, exhibiting an IC50 of 54 nM and a Ki of 148 nM. This compound demonstrates inactivity in IMP-1 and TEM-1 beta-lactamase assays, making it a specific tool for studying VIM-2. Additionally, ML121 has been shown to enhance the antibiotic efficacy of Imipenem in VIM-2 transformed Escherichia coli, positioning it as a valuable reagent in antibiotic research and development.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1212185-26-6
Applications	VIM-2 Inhibitor
Formula	C₁₆H₁₆N₂OS₂
Molecular Weight	316.44
SMILES	O=C1SC(C(C2=CC=CN=C2)C3C(C4CCC3C4)S5)=C5N1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.