Fig. 1 · Structure
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ML267
Sfp-PPTases Inhibitor
ML267 is a potent inhibitor of Sfp phosphopantetheinyl transferases (PPTases), demonstrating an IC50 of 0.29 μM, and also inhibits AcpS-PPTase with an IC50 of 8.1 μM. This compound exhibits specific bactericidal activity against Gram-positive bacteria, making it a valuable tool for studying bacterial metabolism and antibiotic resistance mechanisms. Its selective inhibition profile allows for targeted research in the field of microbiology and antibiotic development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1542213-67-1 |
| Applications | Sfp-PPTases Inhibitor |
| Formula | C19H18ClF6N5O3S |
| Molecular Weight | 545.89 |
| SMILES | S=C(N1CCN(C2=NC=C(C(F)(F)F)C=C2Cl)CC1)NC3=NC=CC(OC)=C3.O=C(O)C(F)(F)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.