ML289 is a selective negative allosteric modulator of the metabotropic glutamate receptor 3 (mGlu3), exhibiting an IC50 value of 0.66 μM. This compound demonstrates over 15-fold selectivity for mGlu3 when compared to mGlu2 and shows no activity against mGlu5. Additionally, ML289 features an alkyne group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc), making it a valuable tool in click chemistry applications and research involving synaptic transmission and neurological disorders.
ML289 is a selective negative allosteric modulator of the metabotropic glutamate receptor 3 (mGlu3), exhibiting an IC50 value of 0.66 μM. This compound demonstrates over 15-fold selectivity for mGlu3 when compared to mGlu2 and shows no activity against mGlu5. Additionally, ML289 features an alkyne group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc), making it a valuable tool in click chemistry applications and research involving synaptic transmission and neurological disorders.
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