Fig. 1 · Structure
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ML289
mGlu3 Negative Allosteric Modulator
ML289 is a selective negative allosteric modulator of the metabotropic glutamate receptor 3 (mGlu3), exhibiting an IC50 value of 0.66 μM. This compound demonstrates over 15-fold selectivity for mGlu3 when compared to mGlu2 and shows no activity against mGlu5. Additionally, ML289 features an alkyne group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc), making it a valuable tool in click chemistry applications and research involving synaptic transmission and neurological disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1382481-79-9 |
| Applications | mGlu3 Negative Allosteric Modulator |
| Formula | C22H23NO3 |
| Molecular Weight | 349.42 |
| Synonyms | VU0463597 |
| SMILES | O=C(N1C[C@H](CO)CCC1)C2=CC=C(C#CC3=CC=C(OC)C=C3)C=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.