Fig. 1 · Structure
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ML291
UPR Signaling Activator
ML291 is a sulfonamidebenzamide that acts as an inducer of the unfolded protein response (UPR). It activates the PERK/eIF2α/CHOP pathway, leading to enhanced apoptosis in various solid tumor models and reducing leukemic cell viability. This compound is valuable for research focused on cancer therapeutics and understanding UPR pathways in cellular stress responses.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inducer |
| CAS Number | 1523437-16-2 |
| Applications | UPR Signaling Activator |
| Formula | C16H16ClN3O6S |
| Molecular Weight | 413.83 |
| SMILES | O=C(C1=CC=C([N+]([O-])=O)O1)NC2=CC=C(S(=O)(N3CCC(Cl)CC3)=O)C=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.