ML337 is a selective negative allosteric modulator of the metabotropic glutamate receptor 3 (mGlu3), exhibiting an IC50 value of 593 nM. This compound demonstrates effective brain penetration and possesses a favorable drug metabolism and pharmacokinetics (DMPK) profile. Furthermore, ML337 serves as a click chemistry reagent, containing an alkyne group capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAC) with azide-containing molecules. Its unique properties make it valuable for studying mGlu3 function and applications in neuropharmacology.
ML337 is a selective negative allosteric modulator of the metabotropic glutamate receptor 3 (mGlu3), exhibiting an IC50 value of 593 nM. This compound demonstrates effective brain penetration and possesses a favorable drug metabolism and pharmacokinetics (DMPK) profile. Furthermore, ML337 serves as a click chemistry reagent, containing an alkyne group capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAC) with azide-containing molecules. Its unique properties make it valuable for studying mGlu3 function and applications in neuropharmacology.
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