Fig. 1 · Structure
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ML352
CHT Inhibitor
ML352 is a noncompetitive inhibitor of the presynaptic choline transporter (CHT), demonstrating Ki values of 92 nM in HEK293 cells expressing human CHT and 166 nM in mouse forebrain synaptosomes. This compound is valuable for research applications focusing on cholinergic signaling and neurotransmitter dynamics, providing insights into synaptic transmission and related neurological disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1649450-12-3 |
| Applications | CHT Inhibitor |
| Formula | C21H29N3O4 |
| Molecular Weight | 387.47 |
| SMILES | CC(C)C1=NOC(CNC(C2=CC(OC3CCN(C)CC3)=C(OC)C=C2)=O)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.