ML353 is a selective allosteric modulator targeting the metabotropic glutamate receptor 5 (mGlu5) with a Ki value of 18.2 nM. This compound enhances the affinity of common allosteric sites, demonstrating a 20-fold improvement over the previous mGlu5 SAM compound. ML353 is suitable for research applications aimed at elucidating the intrinsic activity of silent allosteric modulators in vivo or for use as an agent blocker. Additionally, as a click chemistry reagent featuring an alkyne group, ML353 can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules.
ML353 is a selective allosteric modulator targeting the metabotropic glutamate receptor 5 (mGlu5) with a Ki value of 18.2 nM. This compound enhances the affinity of common allosteric sites, demonstrating a 20-fold improvement over the previous mGlu5 SAM compound. ML353 is suitable for research applications aimed at elucidating the intrinsic activity of silent allosteric modulators in vivo or for use as an agent blocker. Additionally, as a click chemistry reagent featuring an alkyne group, ML353 can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules.
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