Fig. 1 · Structure
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ML353
mGlu5 SAM Ligand
ML353 is a selective allosteric modulator targeting the metabotropic glutamate receptor 5 (mGlu5) with a Ki value of 18.2 nM. This compound enhances the affinity of common allosteric sites, demonstrating a 20-fold improvement over the previous mGlu5 SAM compound. ML353 is suitable for research applications aimed at elucidating the intrinsic activity of silent allosteric modulators in vivo or for use as an agent blocker. Additionally, as a click chemistry reagent featuring an alkyne group, ML353 can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 2990506-75-5 |
| Applications | mGlu5 SAM Ligand |
| Formula | C19H15FN2O |
| Molecular Weight | 306.33 |
| SMILES | O=C(C1=NC=C(C#CC2=CC(F)=CC=C2)C=C1)N(C3)CC4C3C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.