Fig. 1 · Structure
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ML372
SMN Modulator
ML372 is a small molecule SMN modulator that inhibits the ubiquitination of survival motor neuron (SMN) protein, leading to enhanced SMN protein stability without altering mRNA levels. It has demonstrated efficacy in improving spinal muscular atrophy (SMA) models in mice. Additionally, ML372 exhibits good brain penetrance and maintains a favorable pharmacokinetic profile, including reasonable exposure and half-life in vivo, making it a valuable tool for research in SMA therapies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1331745-61-9 |
| Applications | SMN Modulator |
| Formula | C18H20N2O4S |
| Molecular Weight | 360.43 |
| SMILES | O=C(C1CCN(C2=NC=C(C3=CC=C(OCCCO4)C4=C3)S2)CC1)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.