Fig. 1 · Structure
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ML399
Epigenetic Reader Domain Inhibitor
ML399 is an epigenetic reader domain inhibitor that specifically targets the Menin-Mixed Lineage Leukemia (MLL) protein-protein interaction. It has been shown to effectively disrupt the interaction between Menin and MLL fusion proteins, leading to inhibition of oncogenic transcriptional programs in various cancer models. This compound is primarily utilized in research applications focused on the study of acute leukemias and other hematological malignancies linked to MLL rearrangements.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1560968-49-1 |
| Applications | Epigenetic Reader Domain Inhibitor |
| Formula | C27H28FN3O2 |
| Molecular Weight | 445.53 |
| SMILES | O[C@@](C1CCN(CC1)CCCOC2=CC=C(C=C2)C#N)(C3=CC=CC=N3)C4=CC(F)=CC=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.