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ML404

Mitochondrial Permeability Transition Pore Inhibitor

ML404 is a specific inhibitor of the mitochondrial permeability transition pore (mtPTP), effectively suppressing mitochondrial swelling with an EC50 of 4.9 nM. It maintains mitochondrial coupling at concentrations below 100 μM, minimizing adverse effects. This compound is valuable for research in various fields, including multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer's disease, muscular dystrophies, myocardial infarction, and stroke.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1826026-00-9
Applications	Mitochondrial Permeability Transition Pore Inhibitor
Formula	C₁₇H₁₃ClN₂O₃
Molecular Weight	328.75
SMILES	O=C(NC1=CC(Cl)=CC=C1C)C2=NOC(C3=CC=CC(O)=C3)=C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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ML404

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ML404 25 mg