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MLKL-IN-3

MLKL Inhibitor

MLKL-IN-3 is a potent inhibitor of Mixed Lineage Kinase Domain-Like Protein (MLKL), a key player in necroptosis signaling pathways. This compound effectively inhibits necroptosis in HT-29 cells, demonstrating an EC50 of 31 nM, and acts downstream of MLKL phosphorylation. Additionally, MLKL-IN-3 features an alkyne group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions, making it a valuable tool in chemical biology research.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3031406-27-3
Applications	MLKL Inhibitor
Formula	C₃₁H₂₉ClN₄O₆
Molecular Weight	589.04
SMILES	ClC1=C(C(N(C(N1CC#CC2=CC=C(C(CN3C=CC=C(C3=O)OC)=C2)O)=O)C)=O)NC(CCC4=CC=C(C=C4)C)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.