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MLKL-IN-4

MLKL Inhibitor

MLKL-IN-4 is a selective inhibitor of Mixed Linage Kinase Domain-Like protein (MLKL), demonstrating potent inhibition of necroptosis in HT-29 cells with an EC50 of 82 nM. This compound targets the downstream effects of MLKL phosphorylation, making it invaluable for studies on programmed cell death. Additionally, MLKL-IN-4 features an alkyne group, enabling its use as a click chemistry reagent through copper-catalyzed azide-alkyne cycloaddition (CuAAc), facilitating labeling and detection applications in biochemical research.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3031406-17-1
Applications	MLKL Inhibitor
Formula	C₃₀H₂₇ClN₄O₅
Molecular Weight	559.01
SMILES	O=C(NC1=C(Cl)N(CC#CC2=CC=C(O)C(CN3C=CC=CC3=O)=C2)C(N(C)C1=O)=O)CCC4=CC=C(C)C=C4

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.