MLN8054

Catalog No.: A10601

Aurora A Inhibitor

MLN8054 Chemical Structure

CAS NO. 869363-13-3

MLN8054 is an inhibitor of Aurora A kinase, induces senescence in human tumor cells both in vitro and in vivo.

Availability: In stock

Package Price Qty
5 mg
$100.00
10 mg
$180.00
50 mg
$560.00
100 mg
$800.00
10mM * 1mL in DMSO
$120.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

MLN8054 is an inhibitor of Aurora A kinase, induces senescence in human tumor cells both in vitro and in vivo.
Targets
Target Value
AuroraAIC50: 4nM
AuroraBIC50: 172nM
LCKIC50: 3.2μM
PKAIC50: 19μM
CK2IC50: 20.5μM
Chk2IC50: 28μM
PLK1IC50: 53μM
Chk1IC50: >100μM
PKCIC50: >100μM
CaMKIIIC50: >100μM
CDK2EIC50: >100μM
CDK1IC50: >100μM
In vitro (25°C) DMSO 95 mg/mL (199.21 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 15% Captisol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.97 mL 104.84 mL 209.69 mL
0.5 mM 4.19 mL 20.97 mL 41.94 mL
1 mM 2.1 mL 10.48 mL 20.97 mL
5 mM 0.42 mL 2.1 mL 4.19 mL

*The above data is based on the productmolecular weight 476.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10601
Actions Inhibitor
M. Wt 476.9
Formula C25H15ClF2N4O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 869363-13-3
Synonyms MLN-8054
SMILES C1C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)C(=N1)C4=C(C=CC=C4F)F)NC5=CC=C(C=C5)C(=O)O

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