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Aurora A Inhibitor

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Catalog No. A10601

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
MLN8054 5mg A10601-5

Regular Price: $100.00

Special Price: $90.00

MLN8054 10mg A10601-10

Regular Price: $180.00

Special Price: $162.00

MLN8054 50mg A10601-50

Regular Price: $560.00

Special Price: $504.00

MLN8054 100mg A10601-100

Regular Price: $800.00

Special Price: $720.00

MLN8054 10mM * 1mL in DMSO A10601-10mM-D

Regular Price: $120.00

Special Price: $108.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

MLN8054 is an inhibitor of Aurora A kinase, induces senescence in human tumor cells both in vitro and in vivo.


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Chemical Information

Catalog Num A10601
Actions Inhibitor
M. Wt 476.9
Formula C25H15ClF2N4O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 869363-13-3
Synonyms MLN-8054
SMILES C1C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)C(=N1)C4=C(C=CC=C4F)F)NC5=CC=C(C=C5)C(=O)O

Biological Activity

MLN8054 is an inhibitor of Aurora A kinase, induces senescence in human tumor cells both in vitro and in vivo.
Target Value
AuroraAIC50: 4nM
AuroraBIC50: 172nM
LCKIC50: 3.2μM
PKAIC50: 19μM
CK2IC50: 20.5μM
Chk2IC50: 28μM
PLK1IC50: 53μM
Chk1IC50: >100μM
PKCIC50: >100μM
CaMKIIIC50: >100μM
CDK2EIC50: >100μM
CDK1IC50: >100μM


Solubility (25°C) * In vitro DMSO 95 mg/mL (199.21 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 15% Captisol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.97 mL 104.84 mL 209.69mL
0.5 mM 4.19 mL 20.97 mL 41.94 mL
1 mM 2.1 mL 10.48 mL 20.97 mL
5 mM 0.42 mL 2.1 mL 4.19 mL

*The above data is based on the productmolecular weight 476.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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