Fig. 1 · Structure
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MLS1547
Dopamine D2 Receptor Agonist
MLS1547 is a potent G protein-biased agonist of the dopamine D2 receptor (D2R) with a Ki value of 1.2 μM. It effectively stimulates G protein-mediated signaling pathways, exhibiting an EC50 of 0.37 μM in calcium mobilization assays. Additionally, MLS1547 functions as an antagonist for dopamine-stimulated β-arrestin recruitment to the D2R, demonstrating an IC50 of 9.9 μM. This compound is valuable for investigating D2R signaling mechanisms and exploring therapeutic strategies for disorders associated with dopamine dysregulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 315698-36-3 |
| Applications | Dopamine D2 Receptor Agonist |
| Formula | C19H19ClN4O |
| Molecular Weight | 354.83 |
| SMILES | OC1=C2N=CC=CC2=C(Cl)C=C1CN3CCN(C4=NC=CC=C4)CC3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.