Fig. 1 · Structure
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MMAF intermediate 1
Intermediate
MMAF intermediate 1 is a critical precursor in the synthesis of Monomethylauristatin F (MMAF), a potent inhibitor of tubulin polymerization. This compound serves as the cytotoxic component in antibody-drug conjugates (ADCs), contributing to the selective delivery of therapeutic agents to cancer cells. MMAF is utilized in the development of various ADCs, including Vorsetuzumab mafodotin and SGN-CD19A, making this intermediate vital for research in targeted cancer therapies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 161485-82-1 |
| Applications | Intermediate |
| Formula | C24H36N2O6 |
| Molecular Weight | 448.55 |
| SMILES | O=C(N1[C@@H](CCC1)[C@@H]([C@@H](C)C(N[C@H](C(OC)=O)CC2=CC=CC=C2)=O)OC)OC(C)(C)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.