Fig. 1 · Structure
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MMAF intermediate 2
Intermediate
MMAF intermediate 2 is a crucial precursor in the synthesis of MMAF (Monomethylauristatin F), which functions primarily as a potent inhibitor of tubulin polymerization. This intermediate plays a significant role in the development of antibody-drug conjugates (ADCs), such as Vorsetuzumab mafodotin and SGN-CD19A, enhancing their cytotoxic efficacy. Its potential applications in cancer research and therapeutic development make it an essential reagent in the field of targeted drug delivery.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 864238-20-0 |
| Applications | Intermediate |
| Formula | C19H29ClN2O4 |
| Molecular Weight | 384.90 |
| SMILES | O=C(N[C@H](C(OC)=O)CC1=CC=CC=C1)[C@H](C)[C@@H](OC)[C@H]2NCCC2.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.