Fig. 1 · Structure
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MNA 279
Immunosuppressive Agent
MNA 279 is a malononitrilamide derivative and orally active immunosuppressive agent targeting antibody production. It effectively suppresses IgM and IgG antibody levels, demonstrating significant potential in preventing systemic lupus erythematosus (SLE)-like disease in murine models. Additionally, MNA 279 enhances skin xenograft survival in mouse-to-rat transplantation studies, making it a valuable tool for research in autoimmune diseases and transplant immunology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 185915-32-6 |
| Applications | Immunosuppressive Agent |
| Formula | C14H11N3O2 |
| Molecular Weight | 253.26 |
| Synonyms | X 910279; HMR-279; FK-779 |
| SMILES | N#CC1=CC=C(NC(C(C(C2CC2)=O)C#N)=O)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.