MNI137 is a potent and selective negative allosteric modulator targeting group II metabotropic glutamate receptors (mGluRs). With IC50 values of 8.3 nM for human mGlu2 and 12.6 nM for rat mGlu2, MNI137 effectively inhibits glutamate-induced calcium mobilization. This compound is valuable for research applications in neuropharmacology and the exploration of mGluR-related disorders.
MNI137 is a potent and selective negative allosteric modulator targeting group II metabotropic glutamate receptors (mGluRs). With IC50 values of 8.3 nM for human mGlu2 and 12.6 nM for rat mGlu2, MNI137 effectively inhibits glutamate-induced calcium mobilization. This compound is valuable for research applications in neuropharmacology and the exploration of mGluR-related disorders.
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