Fig. 1 · Structure
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MNI137
mGluR Modulator
MNI137 is a potent and selective negative allosteric modulator targeting group II metabotropic glutamate receptors (mGluRs). With IC50 values of 8.3 nM for human mGlu2 and 12.6 nM for rat mGlu2, MNI137 effectively inhibits glutamate-induced calcium mobilization. This compound is valuable for research applications in neuropharmacology and the exploration of mGluR-related disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 946619-21-2 |
| Applications | mGluR Modulator |
| Formula | C15H9BrN4O |
| Molecular Weight | 341.16 |
| SMILES | N#CC1=NC=CC(C2=NC3=CC=C(Br)C=C3NC(C2)=O)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.