Fig. 1 · Structure
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Moexiprilat
Angiotensin-converting Enzyme (ACE)
Moexiprilat is a potent angiotensin-converting enzyme (ACE) inhibitor, with an IC50 of 2.1 nM, and serves as the active metabolite of the prodrug Moexipril. It effectively attenuates the proliferation of primary neonatal rat cardiac fibroblasts stimulated by estrone or angiotensin II at a concentration of 10 nM. Additionally, Moexiprilat lowers mean arterial blood pressure and elevates atrial natriuretic peptide levels, a significant biomarker for hypertension, when administered at a dosage of 50 mg/kg per day in ovariectomized mice.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 103775-14-0 |
| Applications | Angiotensin-converting Enzyme (ACE) |
| Formula | C25H30N2O7 |
| Molecular Weight | 470.51 |
| Synonyms | RS 10029 |
| SMILES | O=C([C@H]1N(C([C@@H](N[C@H](C(O)=O)CCC2=CC=CC=C2)C)=O)CC3=C(C=C(OC)C(OC)=C3)C1)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.