Fig. 1 · Structure
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Mofarotene
Anticancer Compound
Mofarotene, an arotinoid anticancer compound, primarily targets the induction of apoptosis through mechanisms such as mitochondrial membrane depolarization and activation of caspase-3 and -9. This compound is also associated with increased production of reactive oxygen species. In addition, Mofarotene demonstrates the ability to inhibit hematopoiesis in vitro by preventing maturation from primitive progenitor cells, making it valuable for various cancer research applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 125533-88-2 |
| Applications | Anticancer Compound |
| Formula | C29H39NO2 |
| Molecular Weight | 433.63 |
| Synonyms | Ro 40-8757 |
| SMILES | CC1(C2=CC(/C(C)=C/C3=CC=C(C=C3)OCCN4CCOCC4)=CC=C2C(C)(CC1)C)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.