Fig. 1 · Structure
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MOMA-341
WRN Inhibitor
MOMA-341 is a selective inhibitor of Werner RecQ-like helicase (WRN) that functions through an allosteric and ATP-competitive binding mechanism, targeting cysteine 727 of the enzyme. This compound exhibits significant antitumor activity, making it a valuable tool for research on advanced and metastatic solid tumors. Its ability to hinder WRN activity provides insights into cancer biology and the development of therapeutic strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 3078276-74-8 |
| Applications | WRN Inhibitor |
| Formula | C28H26F4N6O3 |
| Molecular Weight | 570.54 |
| SMILES | C=CC(N1CCC2=NN(C3=C2[C@@H](N(CC3)C(C4=C(C(F)=C(N=C4)C(F)(F)F)N)=O)C1)C5=CC=C(C=C5O)C6CC6)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.