Fig. 1 · Structure
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Monascuspiloin
Anti-Androgenic Agent
Monascuspiloin, an anti-androgenic agent, demonstrates potent activity with an IC50 of 7 μM. It reduces viability in prostate cancer cell lines PC-3 and LNCaP, with IC50 values of 45 μM and 47 μM, respectively. Monascuspiloin induces apoptosis in LNCaP cells by inhibiting the Akt/mTOR signaling pathway, promotes autophagy through AMPK activation, and causes G2/M cell cycle arrest in PC-3 cells. Additionally, Monascuspiloin displays antitumor efficacy in murine models, making it a valuable tool for cancer research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1011244-19-1 |
| Applications | Anti-Androgenic Agent |
| Formula | C21H28O5 |
| Molecular Weight | 360.44 |
| Synonyms | Monascinol |
| SMILES | C[C@]12[C@@](CC3=C(COC(/C=C/C)=C3)C2=O)([H])[C@H](C(O1)=O)[C@@H](O)CCCCC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.