Fig. 1 · Structure
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Monomethyl kolavate
TbGAPDH Inhibitor
Monomethyl kolavate is an inhibitor of Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (TbGAPDH), exhibiting an IC50 value of 2 µM. This compound demonstrates significant inhibition of enzyme activity, making it a valuable tool in research focused on kinetoplastid parasites. Its application extends to studies investigating biochemical pathways in parasitic infections, potentially contributing to the development of therapeutic strategies against diseases such as sleeping sickness.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 24513-41-5 |
| Applications | TbGAPDH Inhibitor |
| Formula | C21H32O4 |
| Molecular Weight | 348.48 |
| SMILES | C[C@]12[C@@](CCC=C2C(O)=O)([H])[C@](C)([C@H](C)CC1)CC/C(C)=C/C(OC)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.