Fig. 1 · Structure
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MPP+ iodide
MPTP Metabolite
MPP+ iodide is a neurotoxic metabolite of MPTP that selectively targets dopaminergic neurons in the substantia nigra, leading to Parkinson's disease-like symptoms in animal models. Its primary action involves uptake by the dopamine transporter, where it disrupts mitochondrial function by inhibiting complex I of the respiratory chain. Additionally, MPP+ iodide serves as a high-affinity substrate for the serotonin transporter (SERT), making it a valuable tool for studying neurodegenerative processes and serotonergic activity in research settings.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Substrate |
| CAS Number | 36913-39-0 |
| Applications | MPTP Metabolite |
| Formula | C12H12IN |
| Molecular Weight | 297.14 |
| SMILES | C[N+]1=CC=C(C2=CC=CC=C2)C=C1.[I-] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.