Fig. 1 · Structure
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MreB Perturbing Compound A22 (hydrochloride)
MreB Inhibitor
MreB Perturbing Compound A22 (hydrochloride) is a reversible inhibitor of MreB, targeting bacterial cell shape and division. This compound demonstrates bacteriostatic activity primarily against Escherichia coli, while exhibiting limited effects on Gram-positive bacteria. A22 disrupts the helical and circular organization of MreB within cells, impeding its function and hindering binding to chromosomal regions near the replication origin. Its effects include alterations in cell morphology, impaired growth, and induction of asymmetric division in E. coli. MreB Perturbing Compound A22 is valuable for investigating mechanisms underlying bacterial rod morphology, chromosome segregation, and cell division.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 22816-60-0 |
| Applications | MreB Inhibitor |
| Formula | C8H9Cl3N2S |
| Molecular Weight | 271.59 |
| Synonyms | A22 (hydrochloride) |
| SMILES | ClC1=CC(CSC(N)=N)=CC=C1Cl.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.