MRS2298 is a potent acyclic antagonist of the P2Y1 receptor, exhibiting a Ki of 29.6 nM. This compound effectively inhibits ADP-induced platelet aggregation with an IC50 of 62.8 nM and significantly diminishes Ca2+ mobilization in platelets, presenting an IC50 of 810 nM. MRS2298 serves as a valuable tool for investigating platelet function and the role of purinergic signaling in cardiovascular research.
MRS2298 is a potent acyclic antagonist of the P2Y1 receptor, exhibiting a Ki of 29.6 nM. This compound effectively inhibits ADP-induced platelet aggregation with an IC50 of 62.8 nM and significantly diminishes Ca2+ mobilization in platelets, presenting an IC50 of 810 nM. MRS2298 serves as a valuable tool for investigating platelet function and the role of purinergic signaling in cardiovascular research.
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