MRS2395 is a potent antagonist of the P2Y12 receptor, a key regulator of platelet activity. It effectively inhibits ADP-induced platelet activation with a half-maximal inhibitory concentration (Ki) of 3.6 μM and suppresses cAMP production in rat platelets in the presence of PGE1 with an IC50 of 7 µM. Additionally, MRS2395 promotes the release of dense granules from platelets in response to TRAP-6, making it a valuable tool for research into platelet function and thrombotic disorders.
MRS2395 is a potent antagonist of the P2Y12 receptor, a key regulator of platelet activity. It effectively inhibits ADP-induced platelet activation with a half-maximal inhibitory concentration (Ki) of 3.6 μM and suppresses cAMP production in rat platelets in the presence of PGE1 with an IC50 of 7 µM. Additionally, MRS2395 promotes the release of dense granules from platelets in response to TRAP-6, making it a valuable tool for research into platelet function and thrombotic disorders.
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