MRS4833 is a potent, orally active antagonist of the P2Y14 receptor, exhibiting competitive inhibition with IC50 values of 5.92 nM for human and 4.8 nM for mouse P2Y14R. This compound effectively reduces airway eosinophilia in protease-mediated asthma models and has demonstrated the ability to reverse chronic neuropathic pain in mouse models of chronic constriction injury. MRS4833 is valuable for research investigating P2Y14R-related pathways in asthma and pain management.
MRS4833 is a potent, orally active antagonist of the P2Y14 receptor, exhibiting competitive inhibition with IC50 values of 5.92 nM for human and 4.8 nM for mouse P2Y14R. This compound effectively reduces airway eosinophilia in protease-mediated asthma models and has demonstrated the ability to reverse chronic neuropathic pain in mouse models of chronic constriction injury. MRS4833 is valuable for research investigating P2Y14R-related pathways in asthma and pain management.
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