MRTX-1257-d6 is a deuterium-labeled derivative of MRTX-1257, an irreversible and selective covalent inhibitor targeting KRAS G12C. It exhibits potent biological activity with an IC50 of 900 pM, effectively inhibiting KRAS-dependent ERK phosphorylation in H358 cells. This stable isotope can be utilized in pharmacokinetic studies and metabolic tracing to elucidate the dynamics of KRAS inhibition in cancer research.
MRTX-1257-d6 is a deuterium-labeled derivative of MRTX-1257, an irreversible and selective covalent inhibitor targeting KRAS G12C. It exhibits potent biological activity with an IC50 of 900 pM, effectively inhibiting KRAS-dependent ERK phosphorylation in H358 cells. This stable isotope can be utilized in pharmacokinetic studies and metabolic tracing to elucidate the dynamics of KRAS inhibition in cancer research.
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