Documents & Downloads

MRTX-1257-d6

Stable Isotope

MRTX-1257-d6 is a deuterium-labeled derivative of MRTX-1257, an irreversible and selective covalent inhibitor targeting KRAS G12C. It exhibits potent biological activity with an IC50 of 900 pM, effectively inhibiting KRAS-dependent ERK phosphorylation in H358 cells. This stable isotope can be utilized in pharmacokinetic studies and metabolic tracing to elucidate the dynamics of KRAS inhibition in cancer research.

Out of Stock

Free Aliquoting for Your Order

Tell us your preferred amount per vial. We’ll confirm the options.

Specifications

Manufacturer	Adooq Bioscience
CAS Number	2639608-44-7
Applications	Stable Isotope
Formula	C₃₃H₃₃D₆N₇O₂
Molecular Weight	571.75
SMILES	[2H]C([2H])([2H])N(CCC1)[C@@H]1COC2=NC(N3C[C@@H](N(CC3)C(C=C)=O)CC#N)=C4C(CN(C5=CC=CC6=C5C(C([2H])([2H])[2H])=CC=C6)CC4)=N2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.