MRTX1257

Catalog No.: A17223

KRAS-G12C inhibitor

MRTX1257 Chemical Structure

CAS NO. 2206736-04-9

MRTX1257 is a potent, selective, covalent and irreversible inhibitor of KRAS G12C, MRTX1257 inhibited KRAS dependent ERKphosphorylation in the H358cell assay with an IC50= 900 pM.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $140.00

Special Price $112.00

10 mg

Regular Price: $250.00

Special Price $200.00

50 mg

Regular Price: $900.00

Special Price $720.00

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

MRTX1257 is a potent, selective, covalent and irreversible inhibitor of KRAS G12C, MRTX1257 inhibited KRAS dependent ERKphosphorylation in the H358cell assay with an IC50= 900 pM.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.68 mL 88.38 mL 176.77 mL
0.5 mM 3.54 mL 17.68 mL 35.35 mL
1 mM 1.77 mL 8.84 mL 17.68 mL
5 mM 0.35 mL 1.77 mL 3.54 mL

*The above data is based on the productmolecular weight 565.722. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A17223
Actions Inhibitor
M. Wt 565.722
Formula C33H39N7O2
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 2206736-04-9
Synonyms MRTX-1257; MRTX 1257;
SMILES N#CC[[email protected]@H]1N(C(C=C)=O)CCN(C2=C3C(CN(C4=C5C(C)=CC=CC5=CC=C4)CC3)=NC(OC[[email protected]]6N(C)CCC6)=N2)C1

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