Signaling Pathway
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| Discription | MRTX1257 is a potent, selective, covalent and irreversible inhibitor of KRAS G12C, MRTX1257 inhibited KRAS dependent ERKphosphorylation in the H358cell assay with an IC50= 900 pM. | ||
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| Targets |
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| Catalog Num | A17223 |
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| Formula | C33H39N7O2 |
| Molecular Weight | 565.722 |
| CAS Number | 2206736-04-9 |
| SMILES | N#CC[C@@H]1N(C(C=C)=O)CCN(C2=C3C(CN(C4=C5C(C)=CC=CC5=CC=C4)CC3)=NC(OC[C@H]6N(C)CCC6)=N2)C1 |
| Synonyms | MRTX-1257; MRTX 1257; |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| In vitro | DMSO | 89 mg/mL (157.32 mM) | |
| Water | Insoluble | ||
| Ethanol | 27 mg/mL | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.68 mL | 88.38 mL | 176.77 mL |
| 0.5 mM | 3.54 mL | 17.68 mL | 35.35 mL |
| 1 mM | 1.77 mL | 8.84 mL | 17.68 mL |
| 5 mM | 0.35 mL | 1.77 mL | 3.54 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
