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Biological Activity
MRTX1257 is a potent, selective, covalent and irreversible inhibitor of KRAS G12C, MRTX1257 inhibited KRAS dependent ERKphosphorylation in the H358cell assay with an IC50= 900 pM.
| In vitro | DMSO | 89 mg/mL (157.32 mM) | |
| Water | Insoluble | ||
| Ethanol | 27 mg/mL | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.68 mL | 88.38 mL | 176.77 mL |
| 0.5 mM | 3.54 mL | 17.68 mL | 35.35 mL |
| 1 mM | 1.77 mL | 8.84 mL | 17.68 mL |
| 5 mM | 0.35 mL | 1.77 mL | 3.54 mL |
*The above data is based on the productmolecular weight 565.722. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A17223 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 2206736-04-9 |
| Formula | C33H39N7O2 |
| M. Wt | 565.722 |
| Purity | >98% |
| Synonyms | MRTX-1257; MRTX 1257; |
| SMILES | N#CC[C@@H]1N(C(C=C)=O)CCN(C2=C3C(CN(C4=C5C(C)=CC=CC5=CC=C4)CC3)=NC(OC[C@H]6N(C)CCC6)=N2)C1 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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