MRTX1257

Catalog No.: A17223

KRAS-G12C inhibitor

MRTX1257

MRTX1257 Chemical Structure

CAS NO. 2206736-04-9

MRTX1257 is a potent, selective, covalent and irreversible inhibitor of KRAS G12C, MRTX1257 inhibited KRAS dependent ERKphosphorylation in the H358cell assay with an IC50= 900 pM.

Availability: In stock

Package Price Qty
5 mg
$140.00
10 mg
$250.00
50 mg
$900.00
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Biological Activity

MRTX1257 is a potent, selective, covalent and irreversible inhibitor of KRAS G12C, MRTX1257 inhibited KRAS dependent ERKphosphorylation in the H358cell assay with an IC50= 900 pM.
In vitro DMSO 89 mg/mL (157.32 mM)
Water Insoluble
Ethanol 27 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.68 mL 88.38 mL 176.77 mL
0.5 mM 3.54 mL 17.68 mL 35.35 mL
1 mM 1.77 mL 8.84 mL 17.68 mL
5 mM 0.35 mL 1.77 mL 3.54 mL

*The above data is based on the productmolecular weight 565.722. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A17223
Actions Inhibitor
CAS No. 2206736-04-9
Formula C33H39N7O2
M. Wt 565.722
Purity >98%
Synonyms MRTX-1257; MRTX 1257;
SMILES N#CC[[email protected]@H]1N(C(C=C)=O)CCN(C2=C3C(CN(C4=C5C(C)=CC=CC5=CC=C4)CC3)=NC(OC[[email protected]]6N(C)CCC6)=N2)C1
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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