Fig. 1 · Structure
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MS105
'PTK6 Degrader'
MS105 is a selective degrader of protein tyrosine kinase 6 (PTK6), functioning through the PROTAC mechanism. By recruiting the VHL E3 ligase, MS105 facilitates the ubiquitination and subsequent proteasomal degradation of PTK6. It demonstrates notable biological activity by inhibiting the proliferation and migration of breast cancer cells while also inducing apoptosis. This compound is valuable for research applications focused on breast cancer mechanisms and therapeutic strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 2408339-39-7 |
| Applications | 'PTK6 Degrader' |
| Formula | C56H70FN13O6S |
| Molecular Weight | 1072.30 |
| Synonyms | YX39-105 |
| SMILES | O=C([C@H]1N(C([C@@H](NC(CCCCCCCCNC(CN2CCN(C(C3=CC=C(NC4=NC(C5CC5)=CN6C4=NC=C6C7=CNN=C7)C(F)=C3)=O)CC2)=O)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC8=CC=C(C9=C(C)N=CS9)C=C8 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.