Fig. 1 · Structure
Documents & Downloads
MS31 trihydrochloride
SPIN1 Inhibitor
MS31 trihydrochloride is a selective inhibitor of spindlin 1 (SPIN1), which is known for its role in methyllysine recognition. This compound effectively disrupts the interaction between SPIN1 and the trimethylated lysine marker H3K4me3, exhibiting an IC50 of 77 nM. MS31 trihydrochloride specifically targets Tudor domain II of SPIN1 with a dissociation constant (Kd) of 91 nM, making it a valuable tool for studying methyllysine signaling pathways. Its non-toxic profile to nontumorigenic cells supports potential applications in cancer research and epigenetic studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2748239-18-9 |
| Applications | SPIN1 Inhibitor |
| Formula | C20H30Cl3N3O2 |
| Molecular Weight | 450.83 |
| SMILES | NCC1=CC(CN)=C(OC)C(OCCCN2CC(C=CC=C3)=C3C2)=C1.[H]Cl.[H]Cl.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.