Fig. 1 · Structure
Documents & Downloads
MS437
TSH Receptor Stimulator
MS437 is a potent stimulator of the thyroid-stimulating hormone receptor (TSHR), demonstrating an EC50 value of 13 nM. It effectively activates Gsα, Gαq, and Gα12 pathways, leading to the up-regulation of key genes such as thyroglobulin (Tg) and sodium iodine symporter (NIS). This compound is valuable for research applications focused on thyroid hormone signaling and associated disorders.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Activator |
| CAS Number | 541535-31-3 |
| Applications | TSH Receptor Stimulator |
| Formula | C22H24N2O |
| Molecular Weight | 332.44 |
| SMILES | O=C(C1=C2C(C=CC=C2)=NC(C3=CC=CC=C3)=C1)N(C(C)C)C(C)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.