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MS6178

OTUB1 DUBTAC

MS6178 is a CFTR deubiquitinase-targeted chimera (DUBTAC) that engages OTUB1 to enhance the stability of the ΔF508-CFTR mutant protein. This compound demonstrates a concentration- and time-dependent stabilization effect specifically through OTUB1 recruitment, without altering CFTR mRNA levels. MS6178 is applicable for research in cancer biology and related studies focused on protein stability and degradation pathways.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	3060520-53-5
Applications	OTUB1 DUBTAC
Formula	C₄₇H₅₃F₂N₇O₇S
Molecular Weight	898.03
SMILES	O=C(NC1=NC(C2=CC=CC(C(NCCCCCCC(NCCC3=CC=C(N4CCN(C(/C=C/CN(C)C)=O)CC4=O)S3)=O)=O)=C2)=C(C)C=C1)C5(CC5)C6=CC7=C(OC(F)(F)O7)C=C6

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.