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MS8588

cGAS Activator

MS8588 is a deubiquitinase-targeting chimera (DUBTAC) that activates cGAS. By stabilizing cGAS, MS8588 enhances downstream signaling in the cGAS/STING/IRF3 innate immune pathway. This compound demonstrates significant antitumor activity, making it a valuable tool for investigating immune responses and cancer therapy applications.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	3060519-94-7
Applications	cGAS Activator
Formula	C₄₅H₅₉Cl₂N₉O₆S
Molecular Weight	924.98
SMILES	ClC1=C(NC2=C3CN(C(CO)=O)CC2)C3=C(C4=NN(CCNC(CCCCCCCCCC(NCCC5=CC=C(N6C(CN(C(/C=C/CN(C)C)=O)CC6)=O)S5)=O)=O)C=C4)C=C1Cl

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.