Fig. 1 · Structure
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MSC-1186
SRPK Inhibitor
MSC-1186 is a highly selective pan-SRPK inhibitor targeting SRPK1, SRPK2, and SRPK3, with IC50 values of 2.7 nM, 81 nM, and 0.6 nM, respectively. This compound demonstrates significant biological activity, making it a valuable tool for investigating the role of SRPKs in cancer research. Its selective inhibition of serine/arginine-rich protein kinases supports studies in cellular signaling pathways and provides insights into potential therapeutic strategies for cancer treatment.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2871698-23-4 |
| Applications | SRPK Inhibitor |
| Formula | C19H17ClFN7O2S |
| Molecular Weight | 461.90 |
| SMILES | CS(=O)(N(C1=NC=CC=C1CNC2=NC(C3=NC4=C(F)C(Cl)=CC=C4N3)=NC=C2)C)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.