Fig. 1 · Structure
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MSC2504877
Tankyrase Inhibitor
MSC2504877 is a potent and orally active tankyrase inhibitor, exhibiting IC50 values of 0.0007 µM for TNKS, 0.0008 µM for TNKS2, and 0.54 µM for PARP1. This compound effectively increases AXIN2 and TNKS protein expression while decreasing β-catenin levels, indicating its role in the regulation of key signaling pathways. MSC2504877 demonstrates significant anti-tumor activity, making it a valuable tool for cancer research and therapeutic studies targeting the Wnt signaling pathway.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1460286-21-8 |
| Applications | Tankyrase Inhibitor |
| Formula | C17H18N2O2 |
| Molecular Weight | 282.34 |
| Synonyms | M2912 |
| SMILES | O=C1C2=CC=C(C)N2C=C(C3=CC=C(C(C)(O)C)C=C3)N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.