Fig. 1 · Structure
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MSNBA
GLUT5 Fructose Transport Inhibitor
MSNBA is a selective inhibitor of the GLUT5 fructose transporter, exhibiting an IC50 of 0.10 mM. This compound functions as a competitive inhibitor, demonstrating a Ki value of 3.2 μM in MCF7 cells while showing no impact on human GLUT1, GLUT2, GLUT3, GLUT4, or the bacterial transporter GlcPSe. MSNBA is valuable for research focused on cancer metabolism and diabetes, providing insights into fructose transport regulation and its implications in these conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 852702-51-3 |
| Applications | GLUT5 Fructose Transport Inhibitor |
| Formula | C14H12N2O6S |
| Molecular Weight | 336.32 |
| SMILES | O=[N+](C1=CC(S(=O)(C)=O)=CC=C1NC2=CC3=C(OCO3)C=C2)[O-] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.