MT-1207 is a highly selective antagonist of the adrenergic α1 and 5-HT2A receptors, demonstrating remarkable potency with IC50 values of <0.1 nM for α1A, 0.15 nM for α1B, 1.40 nM for α1D, and 0.27 nM for 5-HT2A. This compound effectively reduces blood pressure in the 2K2C rat model, preserving renal function. MT-1207 is a promising candidate for research into vasodilatation and related cardiovascular therapies.
MT-1207 is a highly selective antagonist of the adrenergic α1 and 5-HT2A receptors, demonstrating remarkable potency with IC50 values of <0.1 nM for α1A, 0.15 nM for α1B, 1.40 nM for α1D, and 0.27 nM for 5-HT2A. This compound effectively reduces blood pressure in the 2K2C rat model, preserving renal function. MT-1207 is a promising candidate for research into vasodilatation and related cardiovascular therapies.
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