MT-1207 is a highly selective antagonist of the adrenergic α1 and 5-HT2A receptors, demonstrating remarkable potency with IC50 values of <0.1 nM for α1A, 0.15 nM for α1B, 1.40 nM for α1D, and 0.27 nM for 5-HT2A. This compound effectively reduces blood pressure in the 2K2C rat model, preserving renal function. MT-1207 is a promising candidate for research into vasodilatation and related cardiovascular therapies.
Fig. 1 · Structure
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MT-1207
α1/5-HT2A Receptor Antagonist
MT-1207 is a highly selective antagonist of the adrenergic α1 and 5-HT2A receptors, demonstrating remarkable potency with IC50 values of <0.1 nM for α1A, 0.15 nM for α1B, 1.40 nM for α1D, and 0.27 nM for 5-HT2A. This compound effectively reduces blood pressure in the 2K2C rat model, preserving renal function. MT-1207 is a promising candidate for research into vasodilatation and related cardiovascular therapies.
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Biological Activity
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1610794-70-1 |
| Applications | α1/5-HT2A Receptor Antagonist |
| Formula | C21H25ClN6S |
| Molecular Weight | 428.98 |
| SMILES | C1(SN=C2N3CCN(CCCCN4N=NC5=C4C=CC=C5)CC3)=C2C=CC=C1.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.