Fig. 1 · Structure
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MT-228
Non-muscle myosin II Inhibitor
MT-228 is a selective inhibitor of non-muscle myosin II with a primary focus on NMIIB, demonstrating a binding affinity (KI) of 1.5 μM, while showing reduced interaction with CMII (KI = 17 μM). This compound is notable for its ability to penetrate the blood-brain barrier, making it suitable for neurological applications. MT-228 exhibits prolonged efficacy in preclinical models of stimulant use disorder, offering potential insights into treatment strategies for related conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2404652-24-8 |
| Applications | Non-muscle myosin II Inhibitor |
| Formula | C19H19N3O3 |
| Molecular Weight | 337.37 |
| Synonyms | BPN-0026709 |
| SMILES | O=C1[C@@]2(O)C(N(C3=CC(OC)=NC=C3)CC2)=NC4=C1C=C(C)C(C)=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.