Fig. 1 · Structure
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Mtb ATP synthase-IN-1
Mtb ATP Synthase Inhibitor
Mtb ATP synthase-IN-1 is a potent inhibitor of Mycobacterium tuberculosis ATP synthase, demonstrating a minimal inhibitory concentration (MIC) of 0.452-0.499 μg/mL against Mtb. This compound exhibits favorable metabolic stability and low cytotoxicity, with a Vero IC50 greater than 64 μg/mL, as well as acceptable oral bioavailability. Mtb ATP synthase-IN-1 is valuable for research focused on developing anti-mycobacterial therapies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2642394-38-3 |
| Applications | Mtb ATP Synthase Inhibitor |
| Formula | C17H13N3O4 |
| Molecular Weight | 323.30 |
| SMILES | O=C1C(C(NC2=CC=C3OCOC3=C2)=C1NCC4=NC=CC=C4)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.