MTEP is a potent non-competitive antagonist of the metabotropic glutamate receptor 5 (mGluR5), exhibiting an IC50 of 5 nM and a Ki of 16 nM. It demonstrates significant antidepressant and anxiolytic-like effects, making it valuable for research related to mood disorders and neurodegenerative diseases such as Parkinson's disease. Additionally, MTEP contains an alkyne functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc), thus serving as a versatile tool in click chemistry applications.
MTEP is a potent non-competitive antagonist of the metabotropic glutamate receptor 5 (mGluR5), exhibiting an IC50 of 5 nM and a Ki of 16 nM. It demonstrates significant antidepressant and anxiolytic-like effects, making it valuable for research related to mood disorders and neurodegenerative diseases such as Parkinson's disease. Additionally, MTEP contains an alkyne functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc), thus serving as a versatile tool in click chemistry applications.
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