Fig. 1 · Structure
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MTEP
mGluR5 Antagonist
MTEP is a potent non-competitive antagonist of the metabotropic glutamate receptor 5 (mGluR5), exhibiting an IC50 of 5 nM and a Ki of 16 nM. It demonstrates significant antidepressant and anxiolytic-like effects, making it valuable for research related to mood disorders and neurodegenerative diseases such as Parkinson's disease. Additionally, MTEP contains an alkyne functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc), thus serving as a versatile tool in click chemistry applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 329205-68-7 |
| Applications | mGluR5 Antagonist |
| Formula | C11H8N2S |
| Molecular Weight | 200.26 |
| SMILES | CC1=NC(C#CC2=CC=CN=C2)=CS1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.