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MTHFD2-IN-5

MTHFD2 Inhibitor

MTHFD2-IN-5 is a selective inhibitor of the enzyme MTHFD2, exhibiting an IC50 of 66 nM. This compound demonstrates notable anticancer activity, particularly against acute myeloid leukemia (AML). Furthermore, MTHFD2-IN-5 has been shown to act synergistically with Alimta to effectively inhibit the proliferation of AML cells, making it a valuable tool for cancer research and therapeutic exploration.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3068001-31-7
Applications	MTHFD2 Inhibitor
Formula	C₁₇H₁₈ClN₇O₇
Molecular Weight	467.82
SMILES	OC(CC[C@@H](C(O)=O)NC(C1=CC(Cl)=C(C=C1)NC(NC2=C(NC(N)=NC2=O)N)=O)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.