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MTHFD2-IN-6

MTHFD2 Inhibitor

MTHFD2-IN-6 is a selective inhibitor of the methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) enzyme. It demonstrates potent inhibition with an IC50 of 1.46 μM for MTHFD2, while also affecting MTHFD1 with an IC50 of 19.05 μM. This compound is valuable for research applications focused on metabolic pathways involving folate metabolism and may contribute to studies on cancer biology and therapeutic strategies targeting MTHFD2.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3077252-76-4
Applications	MTHFD2 Inhibitor
Formula	C₂₁H₂₁ClO₅
Molecular Weight	388.84
SMILES	O=C(C1=C(O)C=C(O)C(C/C=C(C)\C)=C1O)/C=C/C2=CC=C(Cl)C(OC)=C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.