Fig. 1 · Structure
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MTK458
Mitophagy Activator
MTK458 is a potent mitophagy activator that specifically targets PINK1. By binding to PINK1, MTK458 stabilizes an active heterocomplex, thereby enhancing mitophagic processes. This compound is valuable for research related to neurodegenerative diseases, particularly Parkinson's disease, and contributes to understanding mitochondrial quality control mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Activator |
| CAS Number | 2499962-58-0 |
| Applications | Mitophagy Activator |
| Formula | C17H15F3N4 |
| Molecular Weight | 332.32 |
| Synonyms | EP-0035985 |
| SMILES | FC(F)(F)C1=CC(C(N1)=NC=N2)=C2N[C@H]3C4=CC=CC=C4CCC3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.