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MU262

MUS81 Inhibitor

MU262 is a potent inhibitor of the MUS81 enzyme, displaying an IC50 of 0.87 μM. It selectively targets MUS81's catalytic activity without disrupting its DNA binding ability, leading to genomic instability in tumor cells and specifically inhibiting the homologous recombination and break-induced repair pathways. The combination of MU262 with Cisplatin enhances the efficacy of chemotherapy, highlighting its potential as a chemical biology tool for exploring MUS81 function and as a candidate for developing novel anticancer therapies that target DNA repair deficiencies in cancer.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1846587-13-0
Applications	MUS81 Inhibitor
Formula	C₂₀H₁₅FN₆O
Molecular Weight	374.37
SMILES	OC1=C(C2=NC3=CC=CC=C3N2)N=NC4=C(C5=CC=C(F)C=C5)C(CC)=NN41

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.