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MU876

MUS81 Inhibitor

MU876 is a selective MUS81 inhibitor with an IC50 of 0.5 μM. It effectively disrupts MUS81-dependent pathways, including homologous recombination and break-induced replication, thereby sensitizing cancer cells to DNA-damaging agents such as Cisplatin. This compound serves as a valuable tool in cancer chemotherapy research, particularly in studying the mechanisms of DNA repair and the development of therapeutic strategies targeting these pathways.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1208829-24-6
Applications	MUS81 Inhibitor
Formula	C₂₄H₁₈N₆O₃
Molecular Weight	438.44
SMILES	O=C(C1=NOC(C2=CC=CC=C2)=C1)NC3=CC(C4=CC=CC=C4)=NN3C5=NC(C)=CC(N5)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.