Fig. 1 · Structure
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Multi-kinase inhibitor 3
Multikinase Inhibitor
Multi-kinase inhibitor 3 is a potent and orally bioavailable multikinase inhibitor that demonstrates significant activity against multiple targets, including FLT1/VEGFR1, KDR/VEGFR2, FLT4/VEGFR3, FLT3, PDGFRα, and PDGFRβ, with IC50 values ranging from 0.22 nM to 1.59 nM. This compound exhibits strong antiproliferative effects, making it a valuable tool in cancer research applications. Its ability to inhibit key kinases involved in tumor growth and angiogenesis positions Multi-kinase inhibitor 3 as a promising candidate for further investigation in oncological studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2648279-76-7 |
| Applications | Multikinase Inhibitor |
| Formula | C26H26N6O2 |
| Molecular Weight | 454.52 |
| SMILES | CN1N=CC(C2=CC=C(N(C3=CC=C(CC(NC4=CC(C(C)(C)C)=NO4)=O)C=C3)C=N5)C5=C2)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.